Investigation of hazardous chemicals exposure on some liver function enzymes using serum and saliva of Iraqi's students

الملخص

To investigate the potential relevance between health problems and working environment conditions in chemical labs, liver enzymes were examined in both sera and saliva of student volunteers, during the last 15 days of September at which they probably exposed to various chemicals over three months in the Iraqi Chemistry Department. The results showed that there was no significant difference in serum activity for both AST and ALP, however, a significant increase in serum ALT level of Z = -2.355 (p < 0.019), before (median = 4.2 U/l) to after (median = 6.8 U/l) was noticed. Furthermore, the values obtained from salivary AST, ALT and ALP showed highly significant increase of Z= -3.045 (p < 0.002; the median increased from 15 U/l to 31 U/l), Z= -2.512 (p < 0.012; the median increased from 2.7 U/l to 5.0 U/l) and Z=-2.982 (p < 0.003; the median increased from 8.51 U/l to 22.1 U/l) respectively. It can be concluded that the increment of the salivary liver enzymes might explain the slight and early signs of liver dysfunction. Also, the significance correlation obtained between serum and salivary ALP, r = 0.699 (p < 0.005), may be used for pre-clinical diagnosis and monitor various liver dysfunctions caused by exposure to the toxic chemical substances.

DOI = 10.24897/acn.64.68.44