Histopathologic Study in lung & kidney of mice post Infection with Klebsiellae pneumoniae

الملخص

Klebseilla pneumoniae (k. pneumoniae) as opportunistic pathogen caused nosocomial infections 5%–20% of cases from gram-negative bacterial sepsis, and multidrug-resistant in clinical cases a serious health. Klebseilla has the ability to disseminate and colonize most internal organs and the inflammation was rapidly converted from acute to chronic stages. K. pneumonia is a frequent cause of severe pneumonia with extensive lung destruction due to neutrophil infiltration (purulent exudate) in the pulmonary tissue, which is the pathologic lesion of bacterial pneumonia. The present experiment concerned on the histopathologic examination of lung and kidney in mice post- infection intraperitoneal with pathogenic local isolate of k.pneumoniae. Fifty Balb /mice as two groups: 1^st group (n=20) infected with 0.5 ml (2x10⁹ CFU/ml) I/P and 2^nd group (n=20) re-infected as in 1^st group, 3^rd group (n=10) injected I/P with PBS as negative control group. The microscopic lesions of (lung and kidney) post-infection and re-infected were examined. Results: at (4, 8 and 16 hours) the microscopic sections revealed acute inflammatory response, and post 7 days until 14 (re-infection) showed chronic inflammatory response. Conclusions: The roles of pathogenic klebseilla in induction acute infection post few hours which developed to chronic infection post 7 days re-infection.

https://doi.org/10.24897/acn.64.68.204

Keywords: Klebsiella pneumoniae, infection, recurrent infection, pathogenesis of klebsiella pneumonia, histopathology, kidney, lung .